In a recent article, Nicholas A. Meanwell elaborated on the cutting-edge application of bioisosteres in Drug Discovery.
Inspired by this review, we have prepared a set of Building Blocks that share the most prominent carboxylic acid isosteres in marketed drugs. Among them are tetrazoles, acyl sulfonamides, hydroxamic acids, 3-hydroxy oxetanes, and several other acyclic and heterocyclic moieties mentioned in the article.
Discover Chemspace Carboxylic Acid Bioisosteres – a library of 380 in-stock compounds that share more than 15 isosteric types.
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