We are here with a new post from George on Kinase Drug Discovery!
There is a great product on Chemspace, Protein Kinases Targeted Libraries. It has two subsets: General and Allosteric Libraries, which together have about 113K compounds against 115 targets. They were thoughtfully selected by USRCAT by our Molecular Modeling Team.
Protein kinases regulate nearly all aspects of cell life, and alterations in their expression, or mutations in their genes, cause cancer and other diseases. In today’s review, the authors focus on the progress made over the past 20 years in improving the potency and specificity of small-molecule inhibitors of protein and lipid kinases, resulting in the approval of more than 70 new drugs since imatinib was approved in 2001.