George is here with our traditional weekend article!
Today we have a relatively uncommon topic for discussion – pyridones. By the way, the dedicated set of 2000 selected compounds is already available for browsing! You can find it here!
Pyridones have been widely utilized in Drug Discovery. There are some features that exclusively interest scientists in these heterocycles:
- Ability to serve both as hydrogen bond acceptor and donor
- They can act as bioisosteres for amides, phenyls, pyridines, and other nitrogen- or oxygen-containing heterocycles
- They impact a target drug molecule’s lipophilicity, aqueous solubility, and metabolic stability
The review we are featuring today is giving a 20-year overview of the utilization of pyridones in the Drug Discovery process.