Last August, a group of researchers from Germany and Ukraine, published an article 'SAR by space: enriching hit sets from the chemical space', which describes the application of a new "REAL space" concept for mining compounds from vast chemical spaces. The "REAL space" is the world's largest collection of commercially available compounds now containing approximately 13.14 billion molecules, generated from in-stock building blocks based on 183 Enamine synthesis protocols.
Navigation in the REAL Space is a great opportunity for efficient hit finding including scaffold hopping possibilities. Such capabilities of scaffold hopping allow you to explore IP free areas as well as exclude molecules with undesirable physicochemical and ADMET properties. All these compounds could be made on-demand with a high success rate (above 80 %) within 3-4 weeks. Please try this tool on our website!
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