2-(5-methoxy-1H-indol-3-yl)ethan-1-amine

5-Methoxytryptamine: Overview and chemical identifiers

5-Methoxytryptamine is an indoleamine structurally corresponding to the 5-O-methyl derivative of serotonin. The search phrase “5-methoxytryptamine CAS 608-07-1” refers to the neutral compound, not to a salt such as the hydrochloride. Compound form should be confirmed because salts have different compositions and identifiers.

Names, synonyms and CAS 608-07-1

The preferred IUPAC name is 2-(5-methoxy-1H-indol-3-yl)ethanamine. The alternative form 2-(5-methoxy-1H-indol-3-yl)ethan-1-amine describes the same structure. O-Methylserotonin and mexamine are established synonyms. The spelling 5 methoxytryptamine may appear in search queries, but 5-methoxytryptamine is preferred. Hydrochloride products have a different composition and identifiers, so supplier names should be checked against the molecular formula and structure.

Molecular structure and chemical properties

The molecular formula of the neutral compound is C11H14N2O. The queries “5-methoxytryptamine molecular weight” and “molecular weight 5-methoxytryptamine” both refer to 190.24 g/mol for this form. Its structure contains an indole ring with a methoxy group at position 5 and a two-carbon aminoethyl chain at position 3. A valid SMILES representation is COC1=CC2=C(C=C1)NC=C2CCN. The standard InChI is InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3, and the InChIKey is JTEJPPKMYBDEMY-UHFFFAOYSA-N. These values apply to the free base; a salt form has a different formula and molecular weight. Physical form, storage conditions, and hazard information should be taken from the SDS for the exact product.

Applications and research use

5-Methoxytryptamine has been reported as a product of melatonin deacetylation in experimental systems, including rat tissues. This appears to represent a minor metabolic route rather than an intermediate in canonical mammalian melatonin biosynthesis.

Chromatographic and mass-spectrometric methods have been used to measure the compound in biological samples, supporting its use as an analytical reference material. Experimental studies have also used it as an agonist probe in serotonin receptor systems. Reported activity depends on receptor subtype, species, assay format, and compound form and should therefore be interpreted in the context of the relevant experiment.

Sourcing and supplier selection on ChemSpace

ChemSpace presents offers from independent suppliers and is not the manufacturer of the compound. Searches such as “5 methoxytryptamine for sale” may return the free base, hydrochloride products, reference standards, or other catalog forms. Users should confirm that the formula, molecular weight, SMILES, and InChIKey match the intended structure. Selection should be based on the current offer, analytical specification, batch-specific CoA, SDS, and laboratory requirements. Storage and handling should follow product-specific documentation.