We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!


1. NVP-CLR457 is an orally active, potent, non-CNS-penetrating, and well-balanced pan-class IA phosphoinositide 3-kinase (PI3K) inhibitor. PI3 kinases are a part of the PI3K-Akt−mTOR intracellular signaling pathway. The changes in this pathway promote the oncogenesis of multiple cancers. NVP-CLR457 was progressed into Phase I with PI3K-dependent solid tumors.

You can find the analogs to this molecule here!


2. TXA6101 is a bacterial filamentous temperature-sensitive mutant Z (FtsZ) protein inhibitor. FtsZ protein is essential for bacterial cell division and viability. And its inhibitors represent a new drug class targeting Gram-negative bacteria. TXA6101 inhibits the polymerization of E. coli FtsZ in a concentration-dependent manner and induces changes in the morphology of E. coli and K. pneumonia.

You can find the analogs to this molecule here!


Use chem-space.com/search to find off-the-shelf and Make-on-Demand molecules of your interest!

In case of any questions just drop us a line: info@chem-space.com.