A new article featuring Chemspace is out! You can read the full text here!


In this work, the authors identified a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) and demonstrates excellent kinome-wide selectivity. The probe disrupts multiple phases of the lifecycle of β-coronaviruses: viral replication and viral entry. 

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