This April, a group of researchers posted an article called 'The powerful symbiosis between synthetic and medicinal chemistry'.
It combines synthetic chemistry and medicinal chemistry approaches - shows some novel synthetic bioisostere replacements for a number of functional groups.

Based on that, we at Chemspace prepared three great compound sets:

N-trifluoromethyl azoles (1860 compounds) - replacements for secondary trifluoromethyl amines
Phosphine oxides (1520 compounds) - replacements for sulfones, sulfonamides, etc.
1,4-disubstituted 2-oxa-bicyclo[2.1.1]hexanes (1860 compounds) - replacements of a substituted benzene ring.
 

In case of any questions just drop us a line: info@chem-space.com.