We continue our series of posts in the Biologics campaign! Today we focus on the B-Raf proto-oncogene (BRAF).

At Chemspace, we offer various BRAF-related proteins, peptides, RNAs, highly selective antibodies, and kits!

BRAF belongs to the Raf family of serine/threonine protein kinases, playing a crucial role in the mitogen-activated protein kinases (MAPK)/extracellular signal-regulated kinases (ERK) signaling pathway that takes part in cell division, differentiation, and secretion. Mutations in the BRAF gene are linked to cardio-facial-cutaneous syndrome, heart defects, mental retardation, and various cancers.

The BRAF gene mutations, mainly the V600E mutation, contribute to continuous activation of the MAPK/ERK pathway, which leads to cell proliferation and invasion in cancers such as melanoma, colorectal cancer, and multiple myeloma. Although BRAF inhibitors, like vemurafenib (the first drug designed using fragment-based lead discovery), show promise in treating metastatic melanoma, challenges persist.

Got interested? Reach out to us at info@chem-space.com