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ERs play a crucial role in the regulation of gene expression, impacting diverse tissues and organs. Their involvement is especially significant in diseases like breast carcinomas, where ER-positive tumors are prevalent. A deep understanding of ER pathways is essential in unraveling the complexities of hormonal-driven diseases, such as breast and ovarian cancers. One of the challenges in developing drugs against such cancers is mutations and drug resistance, leading to continuous research into ER pathway dysregulations.
