We continue our series of posts in the Biologics campaign! Today, we focus on the glucagon-like peptide-1 receptor (GLP-1R).

At Chemspace, we offer various GLP-1R-related proteins, peptides, RNAs, highly selective antibodies, and kits!

Glucagon-like peptide-1 (GLP-1) is a vital hormone involved in the regulation of glucose homeostasis and appetite control. It is primarily produced by the L-cells of the intestine in response to nutrient ingestion. GLP-1 activates the GLP-1R, a G-protein-coupled receptor abundantly expressed in pancreatic islet cells, the gastrointestinal tract, and the central nervous system.

GLP-1 delays gastric emptying and induces a feeling of satiety, reducing food intake. These effects make GLP-1 a promising target for the treatment of type 2 diabetes (T2D) and obesity. Beyond metabolic regulation, GLP-1R activation influences cardiovascular function, neuroprotection, and cell survival.

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