With the recent FDA approval of Cobenfy - an M1/M4 mAChR-targeting treatment - interest in muscarinic receptor modulation has never been higher.

Earlier, Chemspace represented the M1 mAChR Biologics set (https://chem-space.com/news/biologics-fore-research-muscalinic-receptors), and now we are introducing a carefully selected set for studying the M4 mAChR (https://chem-space.com/biologics/list/fa2d8ce7bc02422ba7935abb9a50ddbf).

The M4 mAChR, encoded by the CHRM4 gene, is primarily expressed in the central nervous system, particularly in regions such as the striatum and cortex. It plays a critical role in modulating neurotransmitter release, regulating neuronal activity, and synaptic plasticity. Dysregulation of M4 mAChR has been implicated in neurological and psychiatric disorders, making it a significant therapeutic target due to its potential to address these diseases by modulating neural pathways without causing peripheral side effects.

Our M4 mAChR Biologics set is designed to support researchers in studying receptor function, localization, and signaling pathways. Whether you are exploring muscarinic receptors or looking for other biologics, we have got you covered.

Explore our biologics collection and contact [email protected] for more information. Let’s accelerate neuroscience research together!