Lactate dehydrogenase A (LDHA) is a promising target in drug discovery due to its central role in glycolysis.

Chemspace offers a carefully selected set of Biologics for studying LDHA (https://chem-space.com/biologics/list/0edcd6dcccd341b58218fd1dc008312c).

LDHA catalyzes the conversion of pyruvate to lactate, a key step in energy production in rapidly proliferating cells, especially tumors. Many cancers are highly dependent on LDHA activity, and its inhibition has been shown to suppress tumor growth, induce apoptosis, and increase sensitivity to chemotherapy and immunotherapy. Beyond oncology, today LDHA is a validated target for treating rare metabolic disorders, such as primary hyperoxaluria. Liver-targeted LDHA inhibitors, such as CHK-336, are currently in development to reduce oxalate production.

Chemspace offers high-quality antibodies, peptides, proteins, clones, kits, lysates, and RNAs to investigate this enzyme's role in both pathological and physiological processes.

If you are interested in LDHA or other targets, or wish to explore our biological services, contact us at [email protected]. We’re here to support your research journey.