This July, Belumosudil (REZUROCK) received approval by the FDA as the treatment of chronic graft versus host disease (cGvHD) in adults and children over 12. It is an orally available inhibitor of Rho-associated coiled-coil kinase 2 (ROCK 2) that binds to and inhibits the serine/threonine kinase activity of ROCK2.
Belumosudil contains quinazoline moiety in its backbone.
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