Dear friends and colleagues!
Join the Chemspace & UCSF Webinar 'Ultra Large-Scale Docking for Receptor Deorphanization', which will take place at 5:00 PM (CET) / 8:00 AM (PST) on March, 4.
J.J. Irwin, R.M. Stein, J.K. Lyu, B.K. Shoichet, B.L. Roth, M.L. Dubocovich, Y.S .Moroz, S. Gahbauer
Department of Pharmaceutical Chemistry, MC 2550
1700 4th St, San Francisco CA 94158-2330, USA
'Receptor deorphanization, the discovery of selective ligands for targets where none was previously known, is an important problem in biology because it enables new research. Molecular docking is a pragmatic approach to use protein structure for novel ligand discovery. Recently, virtual screening libraries have increased in size dramatically, driven by new building block synthesis and new reliable, low-cost reaction schemes.
We will show how molecular docking may be used to discover new ligands for previously orphan receptors, and reveal how the availability of these compounds can lead to new insights in pharmacology.'
 R.M. Stein, et. al, Nature, 2020, 609-614.
Register via the link now!