AV1 has re-emerged as a focus of interest for pharmaceutical companies due to its high potential role in the pathogenesis of autoimmune diseases.

Chemspace offers a carefully curated collection of biologics for studying VAV1 (https://chem-space.com/biologics/list/36e5638ccb1e4cc08fc72560f742827c), including antibodies, proteins, peptides, clones, kits, lysates, and RNAs, to help researchers explore its function and therapeutic potential.

VAV1 is a guanine nucleotide exchange factor that activates Rho family GTPases, and it plays an essential role in T-cell receptor signaling, cytoskeletal rearrangements, and transcriptional activation. Recent studies have shown that dysregulation of VAV1 signaling can alter immune cell activation thresholds, providing opportunities for both immune enhancement (e.g., in cancer) and suppression (e.g., in autoimmunity).

If you are interested in VAV1 or other targets, or would like to explore our biological services, contact us at [email protected]. We are here to support your research journey.