We are happy to continue a new content series - “Molecule Builder”! Here we highlight selected sets of Building Blocks from chem-space.com which can be used as starting materials for analog-synthesis of approved drug molecules.

Olutasidenib (REZLIDHEA) is an oral anticancer drug approved by the FDA for treating relapsed or refractory acute myeloid leukemia (AML). It inhibits mutated isocitrate dehydrogenase-1 (IDH1), which leads to hydroxyglutarate level lowering level and helps the bone marrow adjust the production and differentiation of immature blood cells.

The last step in Olutasidenib synthesis is a reaction of an aminomethyl-dihydro-quinolinone with 1,2-dihydropyridin-2-one halogen derivative.

Two selected sets of Building Blocks, which contain both parts:

Aminomethyl-1,2-dihydroquinolin-2-ones  (556 cmpds) and  1,2-Dihydropyridin-2-one (215 cmpds),

might be a perfect start for your research!