Discover selected sets of Building Blocks in the Chemspace 'Molecule Builder' series for the analog synthesis of recently approved drugs!

In Iptacopan synthesis, a final step involves the reaction of substituted indole with a piperidine derivative. Explore two sets of Building Blocks – indoles (1766 compounds) and substituted piperidines (484 compounds), serving as a perfect starting point for your research.

Iptacopan (FABHALTA®) received FDA approval last December for treating the rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH). This first-in-class, oral, highly selective inhibitor targets factor B (FB), a key component of the alternative pathway (AP) of the complement system. Implicated in various immune responses, the AP also holds promise in treating human diseases like age-related macular degeneration, atypical hemolytic uremic syndrome (aHUS), and various glomerular diseases.