Pritelivir is an AiCuris Anti-infective Cures AG's first-in-class antiviral small molecule targeting the helicase-primase complex, which is an essential for herpes simplex virus (HSV) DNA replication. By blocking this mechanism, pritelivir effectively stops viral replication at its source.
Chemspace supports hit expansion through a range of advanced chemical space exploration approaches. One of these tools is Fuzzy Similarity (FTrees) by BioSolveIT applied across Enamine REAL and Chemspace Freedom spaces. The query molecules are translated into fuzzy pharmacophore descriptors, which are used to search for similar molecules in the chemical spaces with a tree alignment approach.
Here, we showcase analogs of pritelivir that were generated using this method in just seconds, illustrating how quickly Chemspace enables exploration of the chemical space around clinically relevant molecules.
