In 2019, a group of researchers discovered, that azaspiro[3.3]heptanes can act as replacements for morpholines, piperidines, and piperazines in a medicinal chemistry context.
Besides that, the authors concluded that azaspiro[3.3]heptanes are most likely not suitable as bioisosteres, when not used as terminal groups, due to significant changes in their geometry.

Based on the article, we prepared a set of azaspiro[3.3]heptanes, that can become a great start for your research!
You can access it using this link!

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