It is very important to recap success stories, so today’s article featured by George is dedicated to fragment-to-lead (F2L) medicinal chemistry publications in 2021. 

Chemspace has a substantial collection of fragments, and 11 compound sets, including fluorine fragments, spiro fragments, and much more!

You can find the full list of the sets and download them for exploring here!

The authors of this work annually summarize successful F2L studies. They thoroughly analyzed the data to create a table of discovered structures, that features target class, screening methods, and ligand efficiencies. Additionally, they provide their opinions on trends and new developments in fragment-based drug discovery, in particular the use of structural information. 

Check out the full text of the article here!