DNA-encoded library (DEL) is a powerful and broadly applicable small-molecule discovery method that has been increasingly applied to the discovery of chemical probes and novel clinical candidates.
Check out the recent breakthrough that summarizes examples of DEL-mediated discovery and development of novel chemical matter.
Here you can find out more about small molecules discovered from DELs, including their initial identification, optimization, and validation of biological properties. (Nat Rev Drug Discov 2023, doi: 10.1038/s41573-023-00713-6)
We at Chemspace offer a service that combines DNA-encoded libraries (DEL), Machine learning (ML), and access to ultra-large chemical spaces for speeding up the early Drug Discovery process.
This approach is perfect for projects where you have access to purified protein but lack crystal structure or any knowledge about its activity.
For this approach we provide:
- Access to DEL collections up to 4 Billion compounds
- DEL screening services
- ML services
- Hit generation from Enamine REAL – 36 Billion molecules
- Wet screening and hit confirmation
- Hit expansion and follow-up.
