Targeted protein degradation technology evolved a brand-new therapeutic modality and today our weekend article from George is dedicated to this topic.
The authors of the article summarized the latest optimized protein degraders and compared different degradation strategies for the readers to be able to find the most suitable approach for their tasks. The new approaches fix the limitations of the classical degraders - poor draggability and uncontrollable off-target activity. Opportunities and challenges in the topic are being discussed to drive further development.
Besides that, they have some nice graphics, so we highly advise you to check out the full text!
.png)