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IUPAC Name:6-{3-[(4aR,7aS)-hexahydro-2H-[1,4]dioxino[2,3-c]pyrrol-6-yl]propoxy}-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine bis(methanesulfonic acid) hydrate
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:10 days 245 Description: Names: Larotinib (mesylate hydrate); Product Description: Larotinib mesylate hydrate is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC 50 of 0.6 nM .; Target: Btk;EGFR;IRAK; CAS: 2097129-93-4MedChemExpress EUShips from: SwedenTo:10 days 258 Description: Names: Larotinib (mesylate hydrate); Product Description: Larotinib mesylate hydrate is a potent broad-spectrum and orally active tyrosine kinase inhibitor (TKI) with EGFR as the main target with an IC50 of 0.6 nM; Target: Btk;EGFR;IRAK; CAS: 2097129-93-4For a custom pack size or bulk
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IUPAC Name:N-(3-chloro-4-fluorophenyl)-6-(2-{5,8-dioxa-10-azadispiro[2.0.4⁴.3³]undecan-10-yl}ethoxy)-7-methoxyquinazolin-4-amine
Supplier Lead time Price, $ Pack Angene International LimitedShips from: ChinaTo:10 days 393 Description: Simotinib; CAS: 944258-89-3Advanced ChemBlocks CNShips from: ChinaTo:12 days 195 Description: Simotinib; CAS: 944258-89-3A2B ChemShips from: United StatesTo:12 days 492 Description: Simotinib; CAS: 944258-89-3For a custom pack size or bulk
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IUPAC Name:N-(3-chloro-4-fluorophenyl)-6-(2-{5,8-dioxa-10-azadispiro[2.0.4⁴.3³]undecan-10-yl}ethoxy)-7-methoxyquinazolin-4-amine
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:10 days 350 Description: Names: Simotinib; Product Description: Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC 50 of 19.9 nM. Antineoplastic activities .; Target: EGFR; CAS: 944258-89-3MedChemExpress EUShips from: SwedenTo:10 days 369 Description: Names: Simotinib; Product Description: Simotinib is a selective, specific, and orally bioavailable EGFR tyrosine kinase inhibitor, with an IC50 of 19.9 nM. Antineoplastic activities; Target: EGFR; CAS: 944258-89-3Targetmol Chemicals IncShips from: United StatesTo:30 days 1991 mgDescription: Simotinib (AL-6802) is a selective and orally bioactive EGFR tyrosine kinase inhibitor (IC50: 19.9 nM) with anti-tumour activity for the study of non-small cell lung cancer.; CAS: 944258-89-3For a custom pack size or bulk
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CAS: 1626387-95-8IUPAC Name:4-tert-butyl 1-{4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl} (2R)-2-methylpiperazine-1,4-dicarboxylate
Supplier Lead time Price, $ Pack Advanced ChemBlocks CNShips from: ChinaTo:12 days 280 Description: (2R)-1,4-Piperazinedicarboxylic acid, 2-methyl-, 1-[4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl] 4-(1,1-dimethylethyl) ester; CAS: 1626387-95-8ChemScene CNShips from: ChinaTo:15 days 64 Description: 4-(tert-Butyl) 1-(4-((3-chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl) (R)-2-methylpiperazine-1,4-dicarboxylate; CAS: 1626387-95-8For a custom pack size or bulk
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IUPAC Name:7-{[3-({4-[(3-chloro-4-fluorophenyl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]amino}-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide
Supplier Lead time Price, $ Pack A2B ChemShips from: United StatesTo:12 days 524 Description: HX103; CAS: 2566466-98-4Angene USShips from: United StatesTo:15 days 726 Description: HX103; CAS: 2566466-98-4For a custom pack size or bulk
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IUPAC Name:7-{[3-({4-[(3-chloro-4-fluorophenyl)amino]-6-methoxyquinazolin-7-yl}oxy)propyl]amino}-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:10 days 375 Description: Names: HX103; Product Description: HX103 is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-based fluorogenic probe. HX103 inhibits EGFR 19 del , EGFR L858R , EGFR wild type and EGFR T790M with IC 50 s of 1.3, 1.5, 4.0 and 977 nM, respectively. HX103 can be used for quantifying active-EGFR to predict agent sensitivity in NSCLC patients with EGFR-activating mutations .; Target: EGFR; CAS: 2566466-98-4MedChemExpress EUShips from: SwedenTo:10 days 395 Description: Names: HX103; Product Description: HX103 is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)-based fluorogenic probe. HX103 inhibits EGFR 19 del, EGFR L858R, EGFR wild type and EGFR T790M with IC50s of 1.3, 1.5, 4.0 and 977 nM, respectively. HX103 can be used for quantifying active-EGFR to predict agent sensitivity in NSCLC patients with EGFR-activating mutations; Target: EGFR; CAS: 2566466-98-4For a custom pack size or bulk
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IUPAC Name:3-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-N-(8-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}octyl)propanamide
Supplier Lead time Price, $ Pack A2B ChemShips from: United StatesTo:12 days 5571 mgDescription: MS 154; CAS: 2550393-21-8Angene USShips from: United StatesTo:15 days 7691 mgDescription: MS 154; CAS: 2550393-21-8For a custom pack size or bulk
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IUPAC Name:3-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-N-(8-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}octyl)propanamide
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:10 days 400 Description: Names: MS154; Product Description: MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with K d s of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutants. MS154 potently induces the degradation of mutant but not wild-type EGFR in an E3 ligase-dependent manner in cancer cell lines. MS154 potently inhibits cell proliferation in lung cancer cells (Blue: E3 Ligase ligand (HY-103596); Black: linker (HY-W096167); Pink: EGFR ligand (HY-168305)) .; Target: EGFR;PROTACs; CAS: 2550393-21-8MedChemExpress EUShips from: SwedenTo:10 days 421 Description: Names: MS154; Product Description: MS154 is a first-in-class E3 ligase cereblon-recruiting EGFR degrader with Kds of 1.8 nM and 3.8 nM for EGFR WT and EGFR L858R mutants. MS154 potently induces the degradation of mutant but not wild-type EGFR in an E3 ligase-dependent manner in cancer cell lines. MS154 potently inhibits cell proliferation in lung cancer cells (Blue: E3 Ligase ligand (HY-103596); Black: linker (HY-W096167); Pink: EGFR ligand (HY-168305)); Target: EGFR;PROTACs; CAS: 2550393-21-8For a custom pack size or bulk
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IUPAC Name:3-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-N-(8-{[2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}octyl)propanamide
Supplier Lead time Price, $ Pack Angene USShips from: United StatesTo:15 days 6681 mgDescription: MS 154N; CAS: 2675490-97-6For a custom pack size or bulk
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IUPAC Name:3-{4-[3-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)propyl]piperazin-1-yl}-N-(8-{[2-(1-methyl-2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}octyl)propanamide
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:10 days 3401 mgDescription: Names: MS154N; Product Description: MS154N (compound 28) is the negative control of MS39 (HY-157581). MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand Linker is Me-Thalidomide-O-C8-NH2 (HY-168307) .; Target: EGFR;PROTACs; CAS: 2675490-97-6MedChemExpress EUShips from: SwedenTo:10 days 3581 mgDescription: Names: MS154N; Product Description: MS154N (compound 28) is the negative control of MS39 (HY-157581). MS154N is composed of PROTAC target protein ligand EGFR ligand-11 (HY-168305) (red part), E3 ligase ligand 4-Hydroxy-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione (HY-W441376) (blue part) and PROTAC Linker 8-Iodooctan-1-amine (HY-168306) (black part), among which the conjugate of E3 ubiquitin ligase ligand Linker is Me-Thalidomide-O-C8-NH2 (HY-168307); Target: EGFR;PROTACs; CAS: 2675490-97-6For a custom pack size or bulk
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CAS: 2230821-27-7IUPAC Name:(2S,4R)-1-[(2S)-2-[3-(2-{[5-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)pentyl]oxy}ethoxy)propanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
Supplier Lead time Price, $ Pack BLD Pharmatech Co., LimitedShips from: United StatesTo:1 day 21 Description: Name:(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CAS: 2230821-27-7BLD PHARMATECH LTD CNShips from: ChinaTo:1 day 21 Description: Name:(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CAS: 2230821-27-7BLD Pharmatech GmbHShips from: GermanyTo:1 day 10725 mgDescription: Name:(2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; CAS: 2230821-27-7Angene International LimitedShips from: ChinaTo:5 days 16 Description: Gefitinib-based PROTAC 3; CAS: 2230821-27-7Astatech CNShips from: ChinaTo:10 days 186 Description: GEFITINIB-BASED PROTAC 3; CAS: 2230821-27-7AA BLOCKSShips from: United StatesTo:12 days 16 Description: Gefitinib-Based PROTAC 3; CAS: 2230821-27-7A2B ChemShips from: United StatesTo:12 days 29 Description: Gefitinib-based PROTAC 3; CAS: 2230821-27-7ChemScene CNShips from: ChinaTo:15 days 132 Description: Gefitinib-based PROTAC 3; CAS: 2230821-27-7BroadpharmShips from: United StatesTo:20 days 94 Description: Gefitinib-based PROTAC 3; CAS: 2230821-27-7For a custom pack size or bulk
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CAS: 2230821-27-7IUPAC Name:(2S,4R)-1-[(2S)-2-[3-(2-{[5-({4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)pentyl]oxy}ethoxy)propanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
Supplier Lead time Price, $ Pack MedChemExpressShips from: United StatesTo:10 days 132 Description: Names: Gefitinib-based PROTAC 3; Product Description: Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC 50 s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively .; Target: EGFR;PROTACs; CAS: 2230821-27-7MedChemExpress EUShips from: SwedenTo:10 days 139 Description: Names: Gefitinib-based PROTAC 3; Product Description: Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a von Hippel-Lindau ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively; Target: EGFR;PROTACs; CAS: 2230821-27-7Targetmol Chemicals IncShips from: United StatesTo:30 days 38 Description: Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1].; CAS: 2230821-27-7For a custom pack size or bulk
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