We are happy to continue our new inspired by Drug Hunter’s “Small Molecules of the Month” series!

Here are three molecules that were recently highlighted by Drug Hunter!

Using Chemspace will allow you to get off-the-shelf and synthetic analogs to these compounds.

1. "Compound 72" is an inhibitor of protein arginine methyltransferase 5 (PRMT5). PRMT5 is a promising target with growing clinical interest which plays an active role in the development and progression of numerous cancers.

You can find the analogs to this molecule here!

2. "Compound 14" (BMS-986224) is an agonist one of GPSR - apelin receptor (APJ) and drug candidate for heart failure treating. It mimics apelin-13 peptide in cardiovascular disease models and shows sufficient stability and delivery parameters.

You can find the analogs to this molecule here!

3. "Compound 13" (GSK716) is a highly potent and selective corrector of Z α1-antitrypsin. Some hits were identified from the screening of 2 trillion component DNA-encoded library (DEL) and further structure optimization gave this clinical candidate.

You can find the analogs to this molecule here!

Use chem-space.com/search to find analogs for your molecules of interest!