The promising anticancer potential of spiro compounds has enthused medicinal chemists to explore new spiro derivatives with a significantly improved pharmacodynamic and pharmacokinetic profile. This is what is covered in today’s review from George - unfolds various aspects of pharmacological activities and structure-activity relationships (SARs) in several classes of spiro compounds.

The full text of the article is available by this link.

And today we want to remind you about our great Spiro Fragments Compound Set!

All compounds in this set have at least 1 spiro moiety, accord with the Ro3, and are free of PAINS and toxic fragments.

Sounds like a great fit for your research project!