Discover Chemspace tert-Butyl Group Bioisosteres – a library of 160 in-stock compounds that can mimic the properties of this group and be used in library design for further studies.

The tert-butyl group is spread among approved medicines and is widely used in drug design. Compounds with a fluorinated tert-butyl group, as well as trifluoromethyl derivatives of cyclopropane, cyclobutane, and oxetane, which mimic the bulky proportions and non-polar character of the tert-butyl group, are proposed as its replacements in the drug design process.

This flexibility in the design process helps to optimize the properties of the lead compounds by improving the potency, bioavailability, and ADME profiles, as evidenced by research in the field of medicinal chemistry.

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