We are delighted to continue our new content series: 'Molecule Builder'!

Here we highlight selected sets of Building Blocks from chem-space.com, which serve as excellent starting materials for the analog synthesis of recently approved drug molecules.

Fruquintinib (FRUZAQLA®) is a novel, highly selective, and potent oral anticancer drug approved by the FDA for treating metastatic colorectal cancer (mCRC), significantly improving overall survival (OS) in heavily pretreated patients. It functions as a tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3. VEGFRs are crucial regulators of tumor angiogenesis, the process of new blood vessel formation essential for tumor growth and metastasis.

The final step in Fruquintinib synthesis involves a reaction of substituted quinazoline with a benzofuran derivative. Two selected sets of Building Blocks, containing both parts – quinazolines (555 compounds) and bicyclic fused furans (1018 compounds), could be a perfect starting point for your research!