News and Events

Dear friends and colleagues!

Thanks to everyone for joining the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of SM by enzymatic glycosylation'!

For those who didn’t have a chance to connect, the recording is already available!

This was a great PROTACs week! We really hope you enjoyed the campaign.

Today we want to present our new product – PROTACs libraries.

We have put a lot of resources into them, that is why we are proud to finally add them to our website!

Dear friends and colleagues!

Join the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of small molecules by enzymatic glycosylation', which will take place at 5:00 PM (CET) / 8:00 AM (PST) TOMORROW on September 16th, 2021.

The Speaker is Dr. Jørgen Hansen, CSO & CEO at River Stone Bio ApS.

Register via the link now!

The next post about PROTACs is devoted to the application of ubiquitin ligases in the PROTAC drug design.

Dear friends and colleagues!

Join the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of small molecules by enzymatic glycosylation', which will take place at 5:00 PM (CET) / 8:00 AM (PST) on September 16th, 2021.

The Speaker is Dr. Jørgen Hansen, CSO & CEO at River Stone Bio ApS.

Register via the link now!

The third post from our PROTACs campaign is about Azo-PROTACs: a way to control the binding of the molecule using UV/VIS light to reach better specificity.

Based on the azobenzene fragment we prepared a compound set for you!

We are continuing our series of posts on PROTACs!
The second post is devoted to linkers – a crucial part of PROTACs structure. In this publication, the authors talk not only about classical PEG linkers but go more in-depth on other, more complex ones.

If you are interested in this topic, you should totally check it out.

We worked hard to prepare a series of posts on PROTACs - a very promising technique for targeted protein degradation. We will be happy if you enjoy reading our further publications this week or even share them with your colleagues and friends!

Halogenated Amino Phenols are the Molecules of the Month!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

Last year, a review called “Covalent inhibitors: a rational approach to drug discovery” was published by a group of scientists.
This review aims to provide a short historic overview and focus on recently developed covalent inhibitors (2011–2019).

We like the fact that the authors talk about both advantages and possible problems of such components in drug discovery.

Based on this topic, we want to tell you about our Covalent fragments compound libraries!

Last year, a group of researchers published a review called “Next generation organofluorine blockbuster drugs”. This work highlights a section of most successful organo-fluorine drugs (eg. sitagliptin (diabetes), sofosbuvir (hepatitis C), emtricitabine (HIV)), their synthesis, and mode of action.

We want to remind you that we at Chemspace have an amazing library of Fluorine fragments, containing high-quality small molecules with a single fluorine group in each. And all the molecules are in-stock!
To download the library you can use this link!

Meet Chemspace Monthly Digest! 

Here is a summary of all Chemspace news and highlights for August in case you have missed them!

Last month, a group of researchers published an article on the design and synthesis of novel spiro derivatives as potent and reversible Monoacylglycerol Lipase inhibitors (MAGL).

The authors used a structure-based drug discovery strategy to optimize an aromatic HTS hit to the final compound by replacing the binding site of the molecule with aliphatic moieties.

Based on the article, we prepared a set of spirocyclic amides, that can become a great start for your research.

This July, Fexinidazole received approval by the FDA as a drug for the treatment of sleeping sickness.

Fexinidazole shows antiparasitic activity and contains nitroimidazole in its backbone.

We have made a set of Building Blocks, which contain such parts – the perfect start for your research!

Non-classical Amino Acids are the Molecules of This Week!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

Last month, a group of researchers posted an article called ‘Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation’.
The goal of the study was to determine if changing an amine group to sulfonamide or sulfonimidamide in peptides will result in marked differences in their properties.

We caught up the concept and prepared a set of sulfonimidamides for your research!

The chemical space is very huge and this is what our today's article is all about.

We are proud that as time flies Chemspace continues to improve and grow along with it.

Start your search now!     https://chem-space.com/search

Chemspace announces sponsoring of Drug Hunter! We find it very important to popularize science and support creators of scientific content like Drug Hunter!

In a collaboration with @BioSolveIT, Chemspace is proud to offer over 200,000 accessible covalent molecules ready-to-dock in the drug discovery dashboard SeeSAR.

Last September, a group of researchers published a review called ‘Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications’. In this review, several activities of boronic acids, such as anticancer, antibacterial, antiviral activity, and even their application as sensors and delivery systems are addressed.
We at Chemspace also have a great selection of boronic acids, this is why we prepared a set for you!

We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!

We are proud to announce our collaboration with Vision Arcanum!

This company is known for creating and improving an amazing technology of turning hand-drawn formulas into a computer-supported format. They state that it is the most natural way of drawing chemical structures, and we totally agree with that!

Stay tuned for the following updates on our collaboration!

The final post of our Fragment-Based Drug Discovery (FBDD) campaign offers you Fragments compound sets prepared by Chemspace specialists!

Just this Monday, an article featuring Chemspace for synthetic support became available on the Journal of Medicinal Chemistry website.
The authors of the work identified potent biochemical and cell-active lead compounds for understudied kinases like DRAK1, BMP2K, and MARK3/4. We are looking forward to more amazing collaborations and will be very happy to see your science publications featuring our Chemspace!

We are continuing our series of posts on Fragment-Based Drug Discovery (FBDD)!
The third post is devoted to Developing protein-protein interaction inhibitors using FBDD.