News and Events

Chemspace PPI Modulators Library comprises:
- 6K in-stock PPI Modulators of large, but not “greasy” molecules
- molecules accord with the “Rule of 4” for iPPI
- compounds with functional groups that interact with Arg, Trp, Tyr residues.

In February 2020, a group of researchers from the University of California, San Francisco, published an article, which described the application of a new strategy for covalent targeting to the cap-binding site of eukaryotic translation initiation factor 4E (eIF4E) involved in the growth of cancer cells. We at Chemspace selected the Covalent Modifiers Library, which can be used in the covalent docking and available for further purchasing. 

The Molecules of This Week are Hetaryl esters. We at Chemspace always have new small molecules to power up your research. In case of any questions just drop us a line: [email protected].

Chemspace CNS-Focused Library:
✔ high-quality leadlike, free from PAINS/toxic fragments and aggregators, small molecule compounds;
✔ leadlike and druglike compounds with a probability of blood-brain barrier penetration;
✔ selected using physiochemical property filters and computational methods;
✔ 94K in-stock and 547K make-on-demand compounds.

In April 2020, Tucatinib (TUKYSA) received approval by FDA for the treatment of adults with advanced forms of HER2-positive breast cancer. Tucatinib is a kinase inhibitor meaning it blocks a type of enzyme and helps prevent the cancer cells from growing. This drug contains [1,2,4]-triazolo-[1,5-a]-pyridine moiety in its backbone. We have made a set of Building Blocks, which contain such part – the perfect start for your research! 

Chemspace offers the set of compounds that have a proven activity ⟾ Drug Repurposing Library
- the data on a target, a mechanism of action, a clinical status are taken from Broad Repurposing library
- 866 compounds
- full set or cherry-picked selection

Please contact us at [email protected] for more information.

The Molecules of This Week are Hydrazinylphenols. We at Chemspace always have new small molecules to power up your research. In case of any questions just drop us a line: [email protected].

Opicapone (ONGENTYS), approved FDA in April 2020, is designed for the treatment of patients with Parkinson’s disease. It contains 5-phenyl-1,2,4-oxadiazole moiety. We have created a set of BBs with such part:

Enumerated chemical space of small molecules is a space of similar, but different molecules – structural analogues. Chem-space.com comprises the most complete offer of small molecules in one place. Boost your project with new molecules and their analogues – surf and order them through Chem-space.com.

Fight COVID19 libraries have expanded 
+ Part 3 Fight COVID2 = 5,346 ready-to-ship in-stock compounds that are potentially active against CoV-2 Mpro.
More details at [email protected]

The Molecules of This Week are Trifluoroboranuides. We at Chemspace always have new small molecules to power up your research. In case of any questions just drop us a line: [email protected].

Ozanimod (ZEPOSIA), approved FDA in March 2020, is designed for the treatment of Multiple Sclerosis. It contains 5-phenyl-1,2,4-oxadiazole moiety. We have created a set of BBs with such part:

Our RNA-Targeted Library is an excellent basis for drug discovery projects and includes:
~ 15 RNA patterns riboswitches and phosphate binding motifs
~ 4500 compounds
For more details, please contact us at [email protected].

The Molecules of This Week are Ethynylpyrimidine Halides. We at Chemspace always have new small molecules to power up your research. In case of any questions just drop us a line: [email protected].

Start your Screening campaign with our Hit Discovery Pre-Plated set. The set consists of 144K new compounds, which have been selected from our Screening collection, and designed to facilitate the Screening process. This set is assembled of 5 pre-plated subsets.
For more details, please contact us at [email protected].

CHLOROQUINE is a drug that is used to prevent and treat malaria. It is also being studied by FDA to treat COVID-19. It contains a chloroquinoline core. We have created a set of Building Blocks, with such moiety, to generate new ideas for your projects:

Our Fight COVID19 libraries ready to deliver!
2 compound sets were picked out from our catalog, both based on compounds that are active against SARS-CoV/SARS-CoV-2 proteases.
Please contact us at [email protected] for more information.

Press release about Enamine and Chemspace collaborate with Blue Dolphin Lead Discovery has been issued.

The Molecules of This Week are Nitriles. We at Chemspace always have new small molecules to power up your research. In case of any questions just drop us a line: [email protected].

Happy Easter! Let's celebrate with hope, love, and good health. Stay safe!

Use our high-quality Building Blocks for DNA-encoded chemical libraries, take a look at 2-functional and 3-functional "Core" blocks and decorators (a full set or a selected subset based on your criteria). For information just drop us a line on [email protected].

PRETOMANID, approved in August 2019, is an antibiotic used for the treatment of multi-drug-resistant tuberculosis. It contains imidazooxazine core. We have created a set of BBs with such moiety:

We are proud to announce the publication of the article “Virtual screening of the SARS-CoV-2 main protease” was published at https://covid19.galaxyproject.org/.

Meet the Molecules of This Week — Primary Amines. We at Chemspace always have new small molecules to power up your research. In case of any questions just drop us a line: [email protected].

CNS-Focused Library, Drug Impurities Library, Macrocyclic Compounds, RNA-Targeted Library are part of our Screening libraries, the use of which simplifies the selection of molecules from our largest database. All compounds sets with both in-stock and make-on-demand offers. For information just drop us a line on [email protected].