News and Events

Dear friends and colleagues!

Join the Chemspace Webinar 'Fast Structure-Based Virtual Screening in Readily Available Chemical Space of >10 Billion Compounds', which will take place at 5:00 PM (CET) / 8:00 AM (PST) on October 21st, 2021.
The Speaker is Dr. Vsevolod Katritch, Assoc. Professor at the University of Southern California.

Register via the link now!

Our todays’ article is covering the topic, sincerely loved by medicinal chemists – 3D aliphatic molecules, more specifically – bridged pyrrolidines. And of course. we couldn`t forget about an amazing compound set!

We are presenting a great opportunity for your research projects today – a combination of DEL and Machine Learning. Watch the video to find out more!

Hetaryl Primary Amines are the Molecules of the Month!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

Meet Chemspace Monthly Digest! 

Here is a summary of all Chemspace news and highlights for September in case you have missed them!

Acetylenes have been broadly exploited in drug discovery and development and today we want to share a review on them, paired with a great compound set by Chemspace!

We have something very exciting for you! We posted a new collection of more than 2100 in-stock compounds, selected on a pharmacological similarity base against 50 targets on our website. Go check it out!

Chemspace is proud to announce catalog update! Now you will be able to search in 2+ BILLION molecules.

Just last month a group of scientists published an article called ‘Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications’. 
The authors cover the synthesis and introduction of hydroxamic acid groups to various substrates, as well as medicinal chemistry applications of such compounds. Besides that, they mention their physicochemical profile and mutagenicity information, which are important for Drug Discovery projects.  

We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!

Dear friends and colleagues!

Thanks to everyone for joining the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of SM by enzymatic glycosylation'!

For those who didn’t have a chance to connect, the recording is already available!

This was a great PROTACs week! We really hope you enjoyed the campaign.

Today we want to present our new product – PROTACs libraries.

We have put a lot of resources into them, that is why we are proud to finally add them to our website!

Dear friends and colleagues!

Join the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of small molecules by enzymatic glycosylation', which will take place at 5:00 PM (CET) / 8:00 AM (PST) TOMORROW on September 16th, 2021.

The Speaker is Dr. Jørgen Hansen, CSO & CEO at River Stone Bio ApS.

Register via the link now!

The next post about PROTACs is devoted to the application of ubiquitin ligases in the PROTAC drug design.

Dear friends and colleagues!

Join the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of small molecules by enzymatic glycosylation', which will take place at 5:00 PM (CET) / 8:00 AM (PST) on September 16th, 2021.

The Speaker is Dr. Jørgen Hansen, CSO & CEO at River Stone Bio ApS.

Register via the link now!

The third post from our PROTACs campaign is about Azo-PROTACs: a way to control the binding of the molecule using UV/VIS light to reach better specificity.

Based on the azobenzene fragment we prepared a compound set for you!

We are continuing our series of posts on PROTACs!
The second post is devoted to linkers – a crucial part of PROTACs structure. In this publication, the authors talk not only about classical PEG linkers but go more in-depth on other, more complex ones.

If you are interested in this topic, you should totally check it out.

We worked hard to prepare a series of posts on PROTACs - a very promising technique for targeted protein degradation. We will be happy if you enjoy reading our further publications this week or even share them with your colleagues and friends!

Halogenated Amino Phenols are the Molecules of the Month!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

Last year, a review called “Covalent inhibitors: a rational approach to drug discovery” was published by a group of scientists.
This review aims to provide a short historic overview and focus on recently developed covalent inhibitors (2011–2019).

We like the fact that the authors talk about both advantages and possible problems of such components in drug discovery.

Based on this topic, we want to tell you about our Covalent fragments compound libraries!

Last year, a group of researchers published a review called “Next generation organofluorine blockbuster drugs”. This work highlights a section of most successful organo-fluorine drugs (eg. sitagliptin (diabetes), sofosbuvir (hepatitis C), emtricitabine (HIV)), their synthesis, and mode of action.

We want to remind you that we at Chemspace have an amazing library of Fluorine fragments, containing high-quality small molecules with a single fluorine group in each. And all the molecules are in-stock!
To download the library you can use this link!

Meet Chemspace Monthly Digest! 

Here is a summary of all Chemspace news and highlights for August in case you have missed them!

Last month, a group of researchers published an article on the design and synthesis of novel spiro derivatives as potent and reversible Monoacylglycerol Lipase inhibitors (MAGL).

The authors used a structure-based drug discovery strategy to optimize an aromatic HTS hit to the final compound by replacing the binding site of the molecule with aliphatic moieties.

Based on the article, we prepared a set of spirocyclic amides, that can become a great start for your research.

This July, Fexinidazole received approval by the FDA as a drug for the treatment of sleeping sickness.

Fexinidazole shows antiparasitic activity and contains nitroimidazole in its backbone.

We have made a set of Building Blocks, which contain such parts – the perfect start for your research!

Non-classical Amino Acids are the Molecules of This Week!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.