News and Events

The article we want to share today shows, that now it is possible to obtain high-quality 3D reconstructions by cryo-EM without the need for a stabilizing nanobody and with reduced cost.

Dear friends and colleagues!

Join the Chemspace Webinar 'Fast Structure-Based Virtual Screening in Readily Available Chemical Space of >10 Billion Compounds', which will take place at 5:00 PM (CET) / 8:00 AM (PST) TOMORROW, on October 21st, 2021.

The Speaker is Dr. Vsevolod Katritch, Assoc. Professor at the University of Southern California.

Register now via the link!

We are continuing our series of posts on GPCRs!

Determination of GPCRs structures is highly important for classification and SBDD on these targets. This thought is the key point of today’s highlighted article.

We are starting our GPCR information week with a nice review on GPCRomics – its approaches, gaps in knowledge, and future directions.

This year a group of scientists summarized the biological activity of thiazole and oxazole derivatives. We thought this is a great idea to provide you with two compound sets based on it!

Chemspace Catalog is already updated!
This means that now you are able to search in more than 4.3 Billion molecules!

So don’t waste your time and go check out the new compound choices that might become the perfect fit for your research!

https://chem-space.com/search

Dear friends and colleagues!

Join the Chemspace Webinar 'Fast Structure-Based Virtual Screening in Readily Available Chemical Space of >10 Billion Compounds', which will take place at 5:00 PM (CET) / 8:00 AM (PST) on October 21st, 2021.
The Speaker is Dr. Vsevolod Katritch, Assoc. Professor at the University of Southern California.

Register via the link now!

Our todays’ article is covering the topic, sincerely loved by medicinal chemists – 3D aliphatic molecules, more specifically – bridged pyrrolidines. And of course. we couldn`t forget about an amazing compound set!

We are presenting a great opportunity for your research projects today – a combination of DEL and Machine Learning. Watch the video to find out more!

Hetaryl Primary Amines are the Molecules of the Month!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

Meet Chemspace Monthly Digest! 

Here is a summary of all Chemspace news and highlights for September in case you have missed them!

Acetylenes have been broadly exploited in drug discovery and development and today we want to share a review on them, paired with a great compound set by Chemspace!

We have something very exciting for you! We posted a new collection of more than 2100 in-stock compounds, selected on a pharmacological similarity base against 50 targets on our website. Go check it out!

Chemspace is proud to announce catalog update! Now you will be able to search in 2+ BILLION molecules.

Just last month a group of scientists published an article called ‘Hydroxamic Acid Derivatives: From Synthetic Strategies to Medicinal Chemistry Applications’. 
The authors cover the synthesis and introduction of hydroxamic acid groups to various substrates, as well as medicinal chemistry applications of such compounds. Besides that, they mention their physicochemical profile and mutagenicity information, which are important for Drug Discovery projects.  

We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!

Dear friends and colleagues!

Thanks to everyone for joining the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of SM by enzymatic glycosylation'!

For those who didn’t have a chance to connect, the recording is already available!

This was a great PROTACs week! We really hope you enjoyed the campaign.

Today we want to present our new product – PROTACs libraries.

We have put a lot of resources into them, that is why we are proud to finally add them to our website!

Dear friends and colleagues!

Join the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of small molecules by enzymatic glycosylation', which will take place at 5:00 PM (CET) / 8:00 AM (PST) TOMORROW on September 16th, 2021.

The Speaker is Dr. Jørgen Hansen, CSO & CEO at River Stone Bio ApS.

Register via the link now!

The next post about PROTACs is devoted to the application of ubiquitin ligases in the PROTAC drug design.

Dear friends and colleagues!

Join the Chemspace & River Stone Bio ApS Webinar 'Improving characteristics of small molecules by enzymatic glycosylation', which will take place at 5:00 PM (CET) / 8:00 AM (PST) on September 16th, 2021.

The Speaker is Dr. Jørgen Hansen, CSO & CEO at River Stone Bio ApS.

Register via the link now!

The third post from our PROTACs campaign is about Azo-PROTACs: a way to control the binding of the molecule using UV/VIS light to reach better specificity.

Based on the azobenzene fragment we prepared a compound set for you!

We are continuing our series of posts on PROTACs!
The second post is devoted to linkers – a crucial part of PROTACs structure. In this publication, the authors talk not only about classical PEG linkers but go more in-depth on other, more complex ones.

If you are interested in this topic, you should totally check it out.

We worked hard to prepare a series of posts on PROTACs - a very promising technique for targeted protein degradation. We will be happy if you enjoy reading our further publications this week or even share them with your colleagues and friends!

Halogenated Amino Phenols are the Molecules of the Month!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.