News and Events

Last year, a review called “Covalent inhibitors: a rational approach to drug discovery” was published by a group of scientists.
This review aims to provide a short historic overview and focus on recently developed covalent inhibitors (2011–2019).

We like the fact that the authors talk about both advantages and possible problems of such components in drug discovery.

Based on this topic, we want to tell you about our Covalent fragments compound libraries!

Last year, a group of researchers published a review called “Next generation organofluorine blockbuster drugs”. This work highlights a section of most successful organo-fluorine drugs (eg. sitagliptin (diabetes), sofosbuvir (hepatitis C), emtricitabine (HIV)), their synthesis, and mode of action.

We want to remind you that we at Chemspace have an amazing library of Fluorine fragments, containing high-quality small molecules with a single fluorine group in each. And all the molecules are in-stock!
To download the library you can use this link!

Meet Chemspace Monthly Digest! 

Here is a summary of all Chemspace news and highlights for August in case you have missed them!

Last month, a group of researchers published an article on the design and synthesis of novel spiro derivatives as potent and reversible Monoacylglycerol Lipase inhibitors (MAGL).

The authors used a structure-based drug discovery strategy to optimize an aromatic HTS hit to the final compound by replacing the binding site of the molecule with aliphatic moieties.

Based on the article, we prepared a set of spirocyclic amides, that can become a great start for your research.

This July, Fexinidazole received approval by the FDA as a drug for the treatment of sleeping sickness.

Fexinidazole shows antiparasitic activity and contains nitroimidazole in its backbone.

We have made a set of Building Blocks, which contain such parts – the perfect start for your research!

Non-classical Amino Acids are the Molecules of This Week!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

Last month, a group of researchers posted an article called ‘Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation’.
The goal of the study was to determine if changing an amine group to sulfonamide or sulfonimidamide in peptides will result in marked differences in their properties.

We caught up the concept and prepared a set of sulfonimidamides for your research!

The chemical space is very huge and this is what our today's article is all about.

We are proud that as time flies Chemspace continues to improve and grow along with it.

Start your search now!     https://chem-space.com/search

Chemspace announces sponsoring of Drug Hunter! We find it very important to popularize science and support creators of scientific content like Drug Hunter!

In a collaboration with @BioSolveIT, Chemspace is proud to offer over 200,000 accessible covalent molecules ready-to-dock in the drug discovery dashboard SeeSAR.

Last September, a group of researchers published a review called ‘Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications’. In this review, several activities of boronic acids, such as anticancer, antibacterial, antiviral activity, and even their application as sensors and delivery systems are addressed.
We at Chemspace also have a great selection of boronic acids, this is why we prepared a set for you!

We are happy to continue our series of posts, which are inspired by Drug Hunter’s “Small Molecules of the Month”!
Here are two molecules that were recently highlighted by Drug Hunter!

We are proud to announce our collaboration with Vision Arcanum!

This company is known for creating and improving an amazing technology of turning hand-drawn formulas into a computer-supported format. They state that it is the most natural way of drawing chemical structures, and we totally agree with that!

Stay tuned for the following updates on our collaboration!

The final post of our Fragment-Based Drug Discovery (FBDD) campaign offers you Fragments compound sets prepared by Chemspace specialists!

Just this Monday, an article featuring Chemspace for synthetic support became available on the Journal of Medicinal Chemistry website.
The authors of the work identified potent biochemical and cell-active lead compounds for understudied kinases like DRAK1, BMP2K, and MARK3/4. We are looking forward to more amazing collaborations and will be very happy to see your science publications featuring our Chemspace!

We are continuing our series of posts on Fragment-Based Drug Discovery (FBDD)!
The third post is devoted to Developing protein-protein interaction inhibitors using FBDD.

Meet Chemspace Monthly Digest! 

Here is a summary of all Chemspace news and highlights for July in case you have missed them!

We are continuing our series of posts on Fragment-Based Drug Discovery (FBDD)!
The second post is devoted to Covalent fragment libraries in drug discovery.

Sulfamoyl Amines are the Molecules of This Week!

We at Chemspace always have new small molecules to power up your research.

To browse the set please use this link.

We are starting our series of posts on Fragment-Based Drug Discovery today!   

Last April, a group of researchers posted an amazing minireview called 'Library Design Strategies to Accelerate Fragment-Based Drug Discovery'. It provides an overview of library design strategies used to accelerate FBDD by facilitating more efficient fragment screening and/or subsequent fragment-to-hit chemistry.

Definitely worth reading!

This July, a group of researchers posted an article called ‘Current landscape and future perspective of oxazolidinone scaffolds containing antibacterial drugs’.  This work is important because it covers an increasingly serious problem - bacterial resistance to drugs.
The core structure gets modified in order to achieve better molecule parameters and higher activity against bacteria.

We at Chemspace prepared a set of compounds based on phenyl oxazolidinone scaffold for you!

This July, Belumosudil (REZUROCK) received approval by the FDA as the treatment of chronic graft versus host disease (cGvHD). 

It is an orally available inhibitor of Rho-associated coiled-coil kinase 2 (ROCK 2).

Belumosudil contains quinazoline moiety in its backbone.

We have made a set of Building Blocks, which contain such parts – the perfect start for your research!

A new version of Enamine REAL Space is now searchable through Chemspace!

You can access 20 Billion molecules here!

Many thanks to Enamine (https://www.enamine.net) for creating the largest synthetically accessible space and BioSolveIT (https://www.biosolveit.de) for developing an incredible search tool!

In 2019, a group of researchers discovered, that azaspiro[3.3]heptanes can act as replacements for morpholines, piperidines, and piperazines in a medicinal chemistry context.
The authors concluded that azaspiro[3.3]heptanes are most likely not suitable as bioisosteres, when not used as terminal groups.
We prepared a set of azaspiro[3.3]heptanes, that can become a great start for your research!

Dear friends and colleagues!

Thanks to everyone for joining the Chemspace & Vision Arcanum 'Towards a more natural way to draw chemical structures' yesterday!

For those who didn’t have a chance to connect, the recording is already available!